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Article

Deciphering the temporal and spatial mutation dynamics of the SARS-CoV-2 spike glycoprotein.

Physical chemistry chemical physics : PCCP - 29 Jul 2026

Hasan Muhammad, Chen Shihong, Jia Mengqi, Leung Cheuk Fung Alvin, Xu Wentao, Chang Ka Pui, Kan Chi Ming, Yap Shanqi, Bing Yuan, Zhu Kaicheng, Chu Xiakun, Su Haibin

Abstract excerpt

We present a statistical pipeline with two parallel procedures to analyze SARS-CoV-2 spike evolution: (1) probability sequence density analysis for probing its sequence space, and (2) leading mutations by the composite metric. This metric integrates mutation eigenvector information with pairwise couplings to outline evolutionarily significant mutations, coined leading mutations, from massive data sets. Our...

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PMID: 42300480
DOI: 10.1039/d5cp04811g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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