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Article

Variant-driven early warning via unsupervised machine learning analysis of spike protein mutations for COVID-19.

Scientific reports - 3 Jun 2022

de Hoffer Adele, Vatani Shahram, Cot Corentin, Cacciapaglia Giacomo, Chiusano Maria Luisa, Cimarelli Andrea, Conventi Francesco, Giannini Antonio, Hohenegger Stefan, Sannino Francesco

Abstract excerpt

Never before such a vast amount of data, including genome sequencing, has been collected for any viral pandemic than for the current case of COVID-19. This offers the possibility to trace the virus evolution and to assess the role mutations play in its spread within the population, in real time. To this end, we focused on the Spike protein for its central role in mediating viral outbreak and replication in host...

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Identifiers

PMID: 35661750
DOI: 10.1038/s41598-022-12442-8
PMCID: PMC9166699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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