Article
A GWAS top hit for circulating leptin is associated with weight gain but not with leptin protein levels in lithium-augmented patients with major depression.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2021
Bopp Sandra K, Heilbronner Urs, Schlattmann Peter, Buspavanich Pichit J, Lang Undine E, Heinz Andreas, Schulze Thomas G, Adli Mazda, Mühleisen Thomas W, Ricken Roland
Abstract excerpt
Lithium-treated patients often suffer from weight gain as a common adverse event. In an earlier investigation, we found an impact of two single-nucleotide polymorphisms (rs10487506 and rs2278815) at the leptin gene on weight gain but not on leptin protein levels in serum under lithium augmentation. A recent genome-wide association study identified a polymorphism at the leptin gene locus (rs10487505) associated...
Read the complete abstract on PubMed