Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.

doi:10.1016/j.euroneuro.2012.08.010

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Article

Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jul 2013

Kloiber Stefan, Ripke Stephan, Kohli Martin A, Reppermund Simone, Salyakina Daria, Uher Rudolf, McGuffin Peter, Perlis Roy H, Hamilton Steven P, Pütz Benno, Hennings Johannes, Brückl Tanja, Klengel Torsten, Bettecken Thomas, Ising Marcus, Uhr Manfred, Dose Tatjana, Unschuld Paul G, Zihl Josef, Binder Elisabeth, Müller-Myhsok Bertram, Holsboer Florian, Lucae Susanne

Abstract excerpt

Leptin, a peptide hormone from adipose tissue and key player in weight regulation, has been suggested to be involved in sleep and cognition and to exert antidepressant-like effects, presumably via its action on the HPA-axis and hippocampal function. This led us to investigate whether genetic variants in the leptin gene, the level of leptin mRNA-expression and leptin serum concentrations are associated with...

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Identifiers

PMID: 23026132
DOI: 10.1016/j.euroneuro.2012.08.010
PMCID: PMC4221661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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