Article
Droplet digital polymerase chain reaction for the assessment of disease burden in hairy cell leukemia.
Hematological oncology - 1 Feb 2022
Broccoli Alessandro, Terragna Carolina, Nanni Laura, Martello Marina, Armuzzi Silvia, Agostinelli Claudio, Morigi Alice, Casadei Beatrice, Pellegrini Cinzia, Stefoni Vittorio, Sabattini Elena, Argnani Lisa, Zinzani Pier Luigi
Abstract excerpt
BRAFV600E mutation is the pathogenic driver of hairy cell leukemia (HCL) found in the vast majority of cases both at onset and during recurrences. The identification of the mutated allele in blood and marrow correlates with the presence of neoplastic cells and can be considered a marker of active...
Topics
- Biomarkers, Tumor
- Humans
- Leukemia, Hairy Cell
- Mutation
- Neoplasm Recurrence, Local
- Polymerase Chain Reaction
- Prognosis
- Proto-Oncogene Proteins B-raf