Article
Droplet digital PCR analysis of NOTCH1 gene mutations in chronic lymphocytic leukemia.
Oncotarget - 27 Dec 2016
Minervini Angela, Francesco Minervini Crescenzio, Anelli Luisa, Zagaria Antonella, Casieri Paola, Coccaro Nicoletta, Cumbo Cosimo, Tota Giuseppina, Impera Luciana, Orsini Paola, Brunetti Claudia, Giordano Annamaria, Specchia Giorgina, Albano Francesco
Abstract excerpt
In chronic lymphocytic leukemia (CLL), NOTCH1 gene mutations (NOTCH1mut) have been associated with adverse prognostic features but the independence of these as a prognostic factor is still controversial. In our study we validated a c.7541-7542delCT NOTCH1 mutation assay based on droplet digital PCR (ddPCR); we also analyzed the NOTCH1mut allelic burden, expressed as fractional abundance (FA), in 88 CLL patients...
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