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Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells

1 Oct 2021

Abstract excerpt

Rabbit embryos develop as bilaminar discs at gastrulation as in humans and most other mammals, whereas rodents develop as egg cylinders. Primordial germ cells (PGCs) appear to originate during gastrulation according to many systematic studies on mammalian embryos. Here, we show that rabbit PGC (rbPGC) specification occurs at the posterior epiblast at the onset of gastrulation. Using newly derived rabbit...

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PMID: 34644585
DOI: 10.1016/j.celrep.2021.109812

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