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Triple kill: DDR inhibitors, radiotherapy and immunotherapy leave cancer cells with no escape

13 Oct 2022

Abstract excerpt

Radiotherapy (RT) has been widely used in the clinical treatment of cancers, but radiotherapy resistance (RR) leads to RT failure, tumor recurrence and metastasis. Many studies have been performed on the potential mechanisms behind RR, and a strong link has been found between RR and DNA damage. RT-induced DNA damage triggers a protective mechanism called the DNA damage response (DDR). DDR consists of several...

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PMID: 36305726
DOI: 10.3724/abbs.2022153

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