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Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation.

Virus research - 1 Dec 2007

Ayata Minoru, Shingai Masashi, Ning Xiaojun, Matsumoto Misako, Seya Tsukasa, Otani Sanae, Seto Toshiyuki, Ohgimoto Shinji, Ogura Hisashi

Abstract excerpt

Measles virus (MV) is the causative agent of subacute sclerosing panencephalitis (SSPE) and viruses isolated from brains of the patients contain numerous mutations. We have previously demonstrated that the hemagglutinin (H) protein of MV SSPE strains can interact with the signaling lymphocyte activation molecule (SLAM) and an unidentified molecule on Vero cells, but not with CD46, as a receptor. The mechanism by...

Topics

Amino Acid Substitution
Animals
Chlorocebus aethiops
Giant Cells
Humans
Measles virus
Mutant Proteins
Mutation
Subacute Sclerosing Panencephalitis
Vero Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Fusion Proteins

Source

Identifiers

PMID: 17825451
DOI: 10.1016/j.virusres.2007.07.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation.PMID 17825451Read ↗

Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters.Semantic proximity Read ↗

Measles Virus Mutants Possessing the Fusion Protein with Enhanced Fusion Activity Spread Effectively in Neuronal Cells, but Not in Other Cells, without Causing Strong CytopathologySemantic proximity Read ↗

The SI Strain of Measles Virus Derived from a Patient with Subacute Sclerosing Panencephalitis Possesses Typical Genome Alterations and Unique Amino Acid Changes That Modulate Receptor Specificity and Reduce Membrane Fusion ActivitySemantic proximity Read ↗

M protein of subacute sclerosing panencephalitis virus, synergistically with the F protein, plays a crucial role in viral neuropathogenicity.Semantic proximity Read ↗

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A Human Lung Carcinoma Cell Line Supports Efficient Measles Virus Growth and Syncytium Formation via a SLAM- and CD46-Independent MechanismSemantic proximity Read ↗

Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis.Semantic proximity Read ↗

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Multiple Amino Acid Substitutions in Hemagglutinin Are Necessary for Wild-Type MeaslesVirus To Acquire the Ability To Use Receptor CD46 EfficientlySemantic proximity Read ↗

Measles Virus Infects both Polarized Epithelial and Immune Cells by Using Distinctive Receptor-Binding Sites on Its HemagglutininSemantic proximity Read ↗

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