Article
Efficient marmoset genome engineering by autologous embryo transfer and CRISPR/Cas9 technology.
Scientific reports - 12 Oct 2021
Abe Yukiko, Nakao Harumi, Goto Motoki, Tamano Moe, Koebis Michinori, Nakao Kazuki, Aiba Atsu
Abstract excerpt
Genetic engineering of non-human primates, which are most closely related to humans, has been expected to generate ideal animal models for human genetic diseases. The common marmoset (Callithrix jacchus) is a non-human primate species adequate for the production of genetically modified animals because of their small body size and high reproductive capacity. Autologous embryo transfer (AET) is routinely utilized...
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