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A multicenter prospective clinical trial reveals cell-free DNA methylation markers for early esophageal cancer

25 Feb 2025

Abstract excerpt

BACKGROUNDCurrent methods for detecting esophageal cancer (EC) are generally invasive or exhibit limited sensitivity and specificity, especially for the identification of early-stage tumors.METHODSWe identified potential methylated DNA markers (MDMs) from multiple genomic regions in a discovery cohort, and a diagnostic model was developed and verified in a model-verification cohort of 297 participants. The...

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PMID: 39998886
DOI: 10.1172/jci186816

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