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Article

Loops around the Heme Pocket Have a Critical Role in the Function and Stability of BsDyP from Bacillus subtilis.

International journal of molecular sciences - 8 Oct 2021

Rodrigues Carolina F, Borges Patrícia T, Scocozza Magali F, Silva Diogo, Taborda André, Brissos Vânia, Frazão Carlos, Martins Lígia O

Abstract excerpt

Bacillus subtilis BsDyP belongs to class I of the dye-decolorizing peroxidase (DyP) family of enzymes and is an interesting biocatalyst due to its high redox potential, broad substrate spectrum and thermostability. This work reports the optimization of BsDyP using directed evolution for improved oxidation of 2,6-dimethoxyphenol, a model lignin-derived phenolic. After three rounds of evolution, one variant...

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Source

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Identifiers

PMID: 34639208
DOI: 10.3390/ijms221910862
PMCID: PMC8509576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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