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Article

Structural insight into the expanded PCB-degrading abilities of a biphenyl dioxygenase obtained by directed evolution.

Journal of molecular biology - 14 Jan 2011

Kumar Pravindra, Mohammadi Mahmood, Viger Jean-François, Barriault Diane, Gomez-Gil Leticia, Eltis Lindsay D, Bolin Jeffrey T, Sylvestre Michel

Abstract excerpt

The biphenyl dioxygenase of Burkholderia xenovorans LB400 is a multicomponent Rieske-type oxygenase that catalyzes the dihydroxylation of biphenyl and many polychlorinated biphenyls (PCBs). The structural bases for the substrate specificity of the enzyme's oxygenase component (BphAE(LB400)) are largely unknown. BphAE(p4), a variant previously obtained through directed evolution, transforms several...

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Identifiers

PMID: 21073881
DOI: 10.1016/j.jmb.2010.11.009
PMCID: PMC3102011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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