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Article

TNAP: A New Multitask Enzyme in Energy Metabolism.

International journal of molecular sciences - 28 Sept 2021

Briolay Anne, Bessueille Laurence, Magne David

Abstract excerpt

Tissue-nonspecific alkaline phosphatase (TNAP) is mainly known for its necessary role in skeletal and dental mineralization, which relies on the hydrolysis of the mineralization inhibitor inorganic pyrophosphate (PPi). Mutations in the gene encoding TNAP leading to severe hypophosphatasia result in strongly reduced mineralization and perinatal death. Fortunately, the relatively recent development of a recombinant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34638808
DOI: 10.3390/ijms221910470
PMCID: PMC8509042

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