Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.

doi:10.3390/ijms22010051

Article

Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.

International journal of molecular sciences - 23 Dec 2020

Gámez-Belmonte Reyes, Tena-Garitaonaindia Mireia, Hernández-Chirlaque Cristina, Córdova Samir, Ceacero-Heras Diego, de Medina Fermín Sánchez, Martínez-Augustin Olga

Abstract excerpt

The liver expresses tissue-nonspecific alkaline phosphatase (TNAP), which may participate in the defense against bacterial components, in cell regulation as part of the purinome or in bile secretion, among other roles. We aimed to study the role of TNAP in the development of hepatosteatosis. TNAP+/- haplodeficient and wild type (WT) mice were fed a control diet (containing 10% fat w/w) or the same diet deficient...

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