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Article

[Tissue-nonspecific alkaline phosphatase and hypophosphatasia].

Clinical calcium - 1 Feb 2014

Oda Kimimitsu, Kinjoh Natsuko Numa, Sohda Miwa, Komaru Keiichi, Amizuka Norio

Abstract excerpt

There are four isozymes for human alkaline phosphatase (ALP) : tissue-nonspecific ALP (TNSALP), intestinal ALP, placental ALP and germ cell ALP. We present a brief history of TNSALP and review progress in research on it and a rare inborn error of metabolism called hypophosphatasia (HPP), which is caused by various loss-of-function mutations in the ALPL gene encoding TNSALP. HPP is characterized by decreased...

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Source

Identifiers

PMID: 24473356
DOI: CliCa1402233239

Genes

ALPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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