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Article

Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy

28 Sept 2021

Abstract excerpt

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-related condition characterized by increased maternal circulating bile acids (BAs) having adverse fetal effects. We investigated whether the human placenta expresses specific regulation patterns to prevent fetal exposition to harmful amounts of BAs during ICP. Using real-time quantitative PCR, we screened placentae from healthy pregnancies (n = 12) and...

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PMID: 34638773
DOI: 10.3390/ijms221910434

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