Article
Uterine cellular leiomyomas are characterized by common HMGA2 aberrations, followed by chromosome 1p deletion and MED12 mutation: morphological, molecular, and immunohistochemical study of 52 cases.
Virchows Archiv : an international journal of pathology - 1 Feb 2022
Dundr Pavel, Gregová Mária, Hojný Jan, Krkavcová Eva, Michálková Romana, Němejcová Kristýna, Bártů Michaela, Hájková Nikola, Laco Jan, Mára Michal, Richtárová Adéla, Zima Tomáš, Stružinská Ivana
Abstract excerpt
Cellular leiomyoma (CL) represents an uncommon variant of uterine leiomyoma with limited data concerning its immunohistochemical and molecular profile. We performed a comprehensive analysis of 52 CL cases all of which were analyzed immunohistochemically. Molecular analysis was possible in 32 cases with sufficient DNA, and 38 cases with sufficient RNA. The immunohistochemical results showed a high expression of...
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