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BRAF Rearrangements and BRAF V600E Mutations Are Seen in a Subset of Pancreatic Carcinomas With Acinar Differentiation.

Archives of pathology & laboratory medicine - 1 Jul 2022

Ghosh Toshi, Greipp Patricia T, Knutson Darlene, Kloft-Nelson Sara, Jenkins Sarah, Mounajjed Taofic, Said Samar, La Rosa Stefano, Vanoli Alessandro, Sessa Fausto, Naini Bita V, Bellizzi Andrew, Zhang Lizhi, Kerr Sarah E, Graham Rondell P

Abstract excerpt

CONTEXT.—: Comprehensive genomic profiling has demonstrated that approximately 20% of pancreatic carcinomas with acinar differentiation harbor potentially targetable BRAF fusions that activate the MAPK pathway. OBJECTIVES.—: To validate the above finding by BRAF break-apart fluorescence in situ hybridization (FISH) in a large series of pure acinar cell carcinomas (ACCs), evaluate tumors for the presence of BRAF...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34614142
DOI: 10.5858/arpa.2020-0739-OA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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