Successful BRAF/MEK inhibition in a patient with BRAFV600E-mutated extrapancreatic acinar cell carcinoma.

doi:10.1101/mcs.a005553

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Article

Successful BRAF/MEK inhibition in a patient with BRAFV600E-mutated extrapancreatic acinar cell carcinoma.

Cold Spring Harbor molecular case studies - 1 Aug 2020

Busch Elena, Kreutzfeldt Simon, Agaimy Abbas, Mechtersheimer Gunhild, Horak Peter, Brors Benedikt, Hutter Barbara, Fröhlich Martina, Uhrig Sebastian, Mayer Philipp, Schröck Evelin, Stenzinger Albrecht, Glimm Hanno, Jäger Dirk, Springfeld Christoph, Fröhling Stefan, Zschäbitz Stefanie

Abstract excerpt

Pancreatic acinar cell carcinoma (PAC) is a rare disease with a poor prognosis. Treatment options for metastatic PAC are limited and often follow chemotherapeutic regimens for pancreatic ductal adenocarcinoma. Although recurrent genomic alterations, such as BRAF fusions and defects in genes involved in homologous recombination DNA repair, have been described in PAC, data on the clinical efficacy of molecularly...

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PMID: 32843432
DOI: 10.1101/mcs.a005553
PMCID: PMC7476408

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