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Article

SNP-mediated binding of TBX1 to the enhancer element of IL-10 reduces the risk of Behçet's disease.

Epigenomics - 1 Oct 2021

Tan Handan, Su Guannan, Tan Xiao, Qin Yang, Chen Lin, Yuan Gangxiang, Kijlstra Aize, Yang Peizeng

Abstract excerpt

Aims: The genetic association between Behçet's disease susceptibility and IL-10 has been confirmed in multiple cohorts, but the underlying mechanism of this association remains unclear. Materials & methods: We combined public resources and laboratory experiments (electrophoretic mobility shift assays, chromatin immunoprecipitation, luciferase reporter gene and CRISPR/Cas9 genome editing) to analyze transcription...

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Source

Identifiers

PMID: 34612069
DOI: 10.2217/epi-2021-0215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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