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Rescuing eGFP-Tagged Canine Distemper Virus for 40 Serial Passages Separately in Ribavirin- and Non-Treated Cells: Comparative Analysis of Viral Mutation Profiles.

Frontiers in cellular and infection microbiology - 1 Jan 2021

Liu Fuxiao, Wang Ning, Lin Jiahui, Wang Qianqian, Huang Yilan, Zhang Youming, Shan Hu

Abstract excerpt

Due to lacking a proofreading mechanism in their RNA-dependent RNA polymerases (RdRp), RNA viruses generally possess high mutation frequencies, making them evolve rapidly to form viral quasispecies during serial passages in cells, especially treated with mutagens, like ribavirin. Canine distemper virus (CDV) belongs to the genus Morbillivirus. Its L protein functions as an RdRp during viral replication. In this...

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PMID: 34604118
DOI: 10.3389/fcimb.2021.746926
PMCID: PMC8481889

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