Article

Sustained replication of synthetic canine distemper virus defective genomes <i>in vitro</i> and <i>in vivo</i>

2021-06-12

Abstract excerpt

Defective interfering (DI) genomes restrict viral replication and induce type-I interferon. Since DI genomes have been proposed as vaccine adjuvants or therapeutic antiviral agents, it is important to understand their generation, delineate their mechanism of action, develop robust production capacities, assess their safety and in vivo longevity and determine their long-term effects. To address this, we generated...

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Literature Corpus work: b44b5ccb-0874-5f76-bfe9-df34d647e4dd
DOI: 10.1101/2021.06.11.448162

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