The International Association for the Study of Lung Cancer Staging Project: The Impact of Common Molecular Alterations on Overall Survival in NSCLC in Initial Analyses of the IASLC Ninth Edition Staging Database.

doi:10.1016/j.jtho.2025.06.025

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The International Association for the Study of Lung Cancer Staging Project: The Impact of Common Molecular Alterations on Overall Survival in NSCLC in Initial Analyses of the IASLC Ninth Edition Staging Database.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2025

Carbone David P, Hirsch Fred R, Osarogiagbon Raymond Uyiosa, Nishimura Katherine K, Tsao Ming Sound, Travis William D, Yang Dawei, Yang Soo-Ryum, Yatabe Yasushi, Araujo Luiz Henrique, Detterbeck Frank, Lechtenberg Kendra J, Lim Eric, Mack Philip C, Matilla José-María, Montuenga Luis M, Nicholson Andrew G, Suda Kenichi, Terra Ricardo M, Rami-Porta Ramón, Asamura Hisao, Rusch Valerie

Abstract excerpt

INTRODUCTION: TNM staging systems create prognostic categories by anatomic extent of disease. Whether therapeutically important molecular alterations in NSCLC augment the prognostic information of TNM staging is unclear. To study this, we analyzed molecular data from the ninth edition of the lung cancer staging system. METHODS: Eligible patients were diagnosed between 2011 and 2019. Analysis was restricted to the...

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PMID: 40920144
DOI: 10.1016/j.jtho.2025.06.025

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