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Article

Rapalogs induce non-apoptotic, autophagy-dependent cell death in HPV-negative TP53 mutant head and neck squamous cell carcinoma.

Molecular carcinogenesis - 1 Jan 2022

Alam Md Maksudul, Marin Fermin Janmaris, Spiller Patrick T, Burnett Chaning, Rong Xiaohua, Moore-Medlin Tara, Maxwell Caden O, Khandelwal Alok R, Nathan Cherie-Ann O

Abstract excerpt

TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation of the PI3K/AKT/mTOR signaling pathway, we investigated the effect of rapalogs RAD001 and CCI-779 on HPV-negative mutTP53 HNSCC cell lines and xenografts....

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Identifiers

PMID: 34598317
DOI: 10.1002/mc.23357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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