Article
Germline variants in DNA repair genes are associated with young-onset head and neck cancer.
Oral oncology - 1 Nov 2021
Cury Sarah Santiloni, Miranda Priscila Mayrink de, Marchi Fabio Albuquerque, Canto Luisa Matos do, Chulam Thiago Celestino, Petersen Annabeth Høgh, Aagaard Mads M, Pinto Clóvis Antonio Lopes, Kowalski Luiz Paulo, Rogatto Silvia Regina
Abstract excerpt
The genetic predisposition to head and neck carcinomas (HNSCC) and how the known risk factors (papillomavirus infection, alcohol, and tobacco consumption) contribute to the early-onset disease are barely explored. Although HNSCC at early onset is rare, its frequency is increasing in recent years. Germline and somatic variants were assessed to build a comprehensive genetic influence pattern in HNSCC predisposition...
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