Article
A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.
Cancer science - 1 Jun 2021
Koshikawa Nobuko, Yasui Nanami, Kida Yuki, Shinozaki Yoshinao, Tsuji Kohei, Watanabe Takayoshi, Takenaga Keizo, Nagase Hiroki
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations occur frequently in cancer cells, and some of them are often homoplasmic. Targeting such mtDNA mutations could be a new method for killing cancer cells with minimal impact on normal cells. Pyrrole-imidazole polyamides (PIPs) are cell-permeable minor groove binders that show sequence-specific binding to double-stranded DNA and inhibit the transcription of target genes. PIP...
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