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Article

A conformation-specific interhelical salt bridge in the K+ binding site of gastric H,K-ATPase.

The Journal of biological chemistry - 16 Apr 2004

Koenderink Jan B, Swarts Herman G P, Willems Peter H G M, Krieger Elmar, De Pont Jan Joep H H M

Abstract excerpt

Homology modeling of gastric H,K-ATPase based on the E2 model of sarcoplasmic reticulum Ca2+-ATPase (Toyoshima, C., and Nomura, H. (2002) Nature 392, 835-839) revealed the presence of a single high-affinity binding site for K+ and an E2 form-specific salt bridge between Glu820 (M6) and Lys791 (M5). In the E820Q mutant this salt bridge is no longer possible, and the head group of Lys791, together with a water...

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PMID: 14761952
DOI: 10.1074/jbc.M400020200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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