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Article

Evaluation of the genetic toxicity of sofosbuvir and simeprevir with and without ribavirin in a human-derived liver cell line.

Anais da Academia Brasileira de Ciencias - 1 Jan 2021

Librelotto Carina S, Souza Ana Paula DE, Álvares-DA-Silva Mário R, Simon Daniel, Dihl Rafael R

Abstract excerpt

Direct-acting antivirals have revolutionized the treatment of chronic hepatitis C. Sofosbuvir and simeprevir are prescribed worldwide. However, there is a scarcity of information regarding their genotoxicity. Therefore, the present study assessed the cytotoxic and genotoxic effects of sofosbuvir and simeprevir, alone and combined with ribavirin. HepG2 cells were analyzed using the in vitro cytokinesis-block...

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Source

Identifiers

PMID: 34586319
DOI: 10.1590/0001-3765202120200632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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