Article
Genotoxic effect of ribavirin in patients with Crimean-Congo hemorrhagic fever.
Japanese journal of infectious diseases - 1 Oct 2005
Tatar Abdulgani, Ozkurt Zulal, Kiki Ilhami
Abstract excerpt
In this study, we investigated the in vivo genotoxicity of ribavirin in humans, studying 3 patients with Crimean-Congo hemorrhagic fever who were treated with high-dose ribavirin. In order to evaluate genotoxicity, both the micronucleus (MN) test and the sister chromatid exchange (SCE) test were used. In all patients, blood samples were taken during and after therapy. Whole blood cultures were performed for 72 h...
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