Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary genetics and acclimatization in nephrology.

Nature reviews. Nephrology - 1 Dec 2021

Adeyemo Adebowale A, Shriner Daniel, Bentley Amy R, Gbadegesin Rasheed A, Rotimi Charles N

Abstract excerpt

Evolutionary processes, including mutation, migration and natural selection, have influenced the prevalence and distribution of various disorders in humans. However, despite a few well-known examples, such as the APOL1 variants - which have undergone positive genetic selection for their ability to confer resistance to Trypanosoma brucei infection but confer a higher risk of chronic kidney disease - little is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acclimatization
Share to Apolipoprotein L1
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome

Share to Kidney Diseases

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 34584272
DOI: 10.1038/s41581-021-00483-7
PMCID: PMC8478000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary genetics and acclimatization in nephrology.PMID 34584272Read ↗

Genetics of kidney failure and the evolving story of APOL1.Semantic proximity Read ↗

APOL1 and Kidney Disease: From Genetics to Biology.Semantic proximity Read ↗

APOL1 Nephropathy: A Population Genetics and Evolutionary Medicine Detective Story.Semantic proximity Read ↗

Population genetics of chronic kidney disease: the evolving story of APOL1.Semantic proximity Read ↗

A Brief History of APOL1: A Gene Evolving.Semantic proximity Read ↗

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease.Semantic proximity Read ↗

Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic EffectsSemantic proximity Read ↗

APOL1 risk variants and kidney disease: what we know so far.Semantic proximity Read ↗

Evolutionary immunology: how your ancestry can affect your kidney transplant.Semantic proximity Read ↗

Genetics of kidney traits in worldwide populations: the Continental Origins and Genetic Epidemiology Network (COGENT) Kidney ConsortiumSemantic proximity Read ↗

Gene of the month: APOL1.Semantic proximity Read ↗

Genes and environment in chronic kidney disease hotspotsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.