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Article

Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics.

Current opinion in genetics & development - 1 Dec 2021

Hayward Samuel B, Ciccia Alberto

Abstract excerpt

CRISPR-dependent genome editing enables the study of genes and mutations on a large scale. Here we review CRISPR-based functional genomics technologies that generate gene knockouts and single nucleotide variants (SNVs) and discuss how their use has provided new important insights into the function of homologous recombination (HR) genes. In particular, we highlight discoveries from CRISPR screens that have...

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Identifiers

PMID: 34583241
DOI: 10.1016/j.gde.2021.08.006
PMCID: PMC8671205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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