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Article

Knocking out TMEM38B in human foetal osteoblasts hFOB 1.19 by CRISPR/Cas9: A model for recessive OI type XIV.

PloS one - 1 Jan 2021

Leoni Laura, Tonelli Francesca, Besio Roberta, Gioia Roberta, Moccia Francesco, Rossi Antonio, Forlino Antonella

Abstract excerpt

Osteogenesis imperfecta (OI) type XIV is a rare recessive bone disorder characterized by variable degree of severity associated to osteopenia. It is caused by mutations in TMEM38B encoding for the trimeric intracellular cation channel TRIC-B, specific for potassium and ubiquitously present in the endoplasmic reticulum (ER) membrane. OI type XIV molecular basis is largely unknown and, due to the rarity of the...

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Identifiers

PMID: 34582479
DOI: 10.1371/journal.pone.0257254
PMCID: PMC8478202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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