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Article

Activation of the PI3K-AKT signaling pathway by SPARC contributes to the malignant phenotype of cholangiocarcinoma cells.

Tissue & cell - 1 Jun 2022

Deng Shikang, Zhang Li, Li Jiao, Jin Yan, Wang Junfeng

Abstract excerpt

Cholangiocarcinoma (CCA) is a primary biliary epithelium malignancy with limited therapies, poor prognosis and high mortality rate. Nowadays, the molecular mechanisms of CCA remain elusive. SPARC has been proposed to be highly expressed in clinical CCA tissues, but few studies has been elucidated its functions in CCA. In the current study, we aimed to investigate the functional role of SPARC in the progression of...

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PMID: 35217388
DOI: 10.1016/j.tice.2022.101756

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