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Antibody-Mediated Neutralization of Authentic SARS-CoV-2 B.1.617 Variants Harboring L452R and T478K/E484Q.

Viruses - 26 Aug 2021

Wilhelm Alexander, Toptan Tuna, Pallas Christiane, Wolf Timo, Goetsch Udo, Gottschalk Rene, Vehreschild Maria J G T, Ciesek Sandra, Widera Marek

Abstract excerpt

The capacity of convalescent and vaccine-elicited sera and monoclonal antibodies (mAb) to neutralize SARS-CoV-2 variants is currently of high relevance to assess the protection against infections. We performed a cell culture-based neutralization assay focusing on authentic SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta), B.1.427/B.1.429 (Epsilon), all harboring the spike substitution L452R. We found that...

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Identifiers

PMID: 34578275
DOI: 10.3390/v13091693
PMCID: PMC8473269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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