Article
Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.
Cell research - 1 Jul 2021
Cao Yunlong, Yisimayi Ayijiang, Bai Yali, Huang Weijin, Li Xiaofeng, Zhang Zhiying, Yuan Tianjiao, An Ran, Wang Jing, Xiao Tianhe, Du Shuo, Ma Wenping, Song Liyang, Li Yongzheng, Li Xiang, Song Weiliang, Wu Jiajing, Liu Shuo, Li Xuemei, Zhang Yonghong, Su Bin, Guo Xianghua, Wei Yangyang, Gao Chuanping, Zhang Nana, Zhang Yifei, Dou Yang, Xu Xiaoyu, Shi Rui, Lu Bai, Jin Ronghua, Ma Yingmin, Qin Chengfeng, Wang Youchun, Feng Yingmei, Xiao Junyu, Xie Xiaoliang Sunney
Abstract excerpt
SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain (RBD) and N-terminal domain (NTD). Here we report the humoral immune response to circulating SARS-CoV-2 variants, such as 501Y.V2 (B.1.351), of the plasma and neutralizing antibodies (NAbs) elicited by CoronaVac (inactivated vaccine), ZF2001 (RBD-subunit vaccine) and natural infection. Among 86 potent NAbs identified by...
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