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Article

Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation.

International journal of molecular sciences - 18 Sept 2021

Nisticò Clelia, Pagliari Francesca, Chiarella Emanuela, Fernandes Guerreiro Joana, Marafioti Maria Grazia, Aversa Ilenia, Genard Geraldine, Hanley Rachel, Garcia-Calderón Daniel, Bond Heather Mandy, Mesuraca Maria, Tirinato Luca, Spadea Maria Francesca, Seco Joao Carlos

Abstract excerpt

Breast cancer is the most frequent cancer in women worldwide and late diagnosis often adversely affects the prognosis of the disease. Radiotherapy is commonly used to treat breast cancer, reducing the risk of recurrence after surgery. However, the eradication of radioresistant cancer cells, including cancer stem cells, remains the main challenge of radiotherapy. Recently, lipid droplets (LDs) have been proposed...

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Share to Diacylglycerol O-Acyltransferase
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

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Identifiers

PMID: 34576263
DOI: 10.3390/ijms221810102
PMCID: PMC8466244

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