Quercetin Affects Carcinogenic Phenotype of Breast and Lung Cancer Cells Differentially Through Sterol Regulation Mediated by MALAT1 Perturbation.

Abstract excerpt

Targeting MALAT1 in cancer treatment is an attractive strategy due to the undebatable role of this lncRNA in the disease. Small molecules toward this noncoding RNA have, in fact, entered preclinical trials, without resulting in a robust demonstration in favor of their use in therapy. To test the robustness of this method, we asked how aspects of carcinogenesis get affected when knocking down MALAT1 in different...

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