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Geographical clusters of amyotrophic lateral sclerosis and the Bradford Hill criteria.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2022

Longinetti Elisa, Pupillo Elisabetta, Belometti Chiara, Bianchi Elisa, Poloni Marco, Fang Fang, Beghi Ettore

Abstract excerpt

With the aim of shedding further light on the role of environmental factors in amyotrophic lateral sclerosis (ALS) etiology, we hereby conducted a historical narrative review to critically appraise the published reports on ALS geographical clusters using the modern interpretation of the Bradford Hill criteria for causation. Our research hypothesis was that the more criteria were met, the greater was the evidence...

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PMID: 34565247
DOI: 10.1080/21678421.2021.1980891

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