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Article

Metal(loid)s role in the pathogenesis of amyotrophic lateral sclerosis: Environmental, epidemiological, and genetic data.

Environmental research - 1 Jan 2021

Tesauro Marina, Bruschi Maurizio, Filippini Tommaso, D'Alfonso Sandra, Mazzini Letizia, Corrado Lucia, Consonni Michela, Vinceti Marco, Fusi Paola, Urani Chiara

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder of the motor system. The etiology is still unknown and the pathogenesis remains unclear. ALS is familial in the 10% of cases with a Mendelian pattern of inheritance. In the remaining sporadic cases, a multifactorial origin is supposed in which several predisposing genes interact with environmental factors. The etiological role of...

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PMID: 33027627
DOI: 10.1016/j.envres.2020.110292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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