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Article

Helicobacter pylori CagA EPIYA Motif Variations Affect Metabolic Activity in B Cells.

Toxins - 24 Aug 2021

Diechler Sebastian, Chichirau Bianca E, Posselt Gernot, Sgouras Dionyssios N, Wessler Silja

Abstract excerpt

BACKGROUND: Helicobacter pylori (Hp) colonizes the human stomach and can induce gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. Clinical observations suggest a role for the Hp virulence factor cytotoxin-associated gene A (CagA) in pathogenesis. The pathogenic activity of CagA is partly regulated by tyrosine phosphorylation of C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs in host cells....

Topics

Cytotoxins
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Neoplastic
Genetic Variation
Genotype
Helicobacter Infections
Helicobacter pylori
Host-Pathogen Interactions
Humans
Lymphoma, B-Cell, Marginal Zone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 34564597
DOI: 10.3390/toxins13090592
PMCID: PMC8473296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34564597-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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