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Article

Helicobacter pylori CagA EPIYA Motif Variations Affect Metabolic Activity in B Cells.

Toxins - 24 Aug 2021

Diechler Sebastian, Chichirau Bianca E, Posselt Gernot, Sgouras Dionyssios N, Wessler Silja

Abstract excerpt

BACKGROUND: Helicobacter pylori (Hp) colonizes the human stomach and can induce gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. Clinical observations suggest a role for the Hp virulence factor cytotoxin-associated gene A (CagA) in pathogenesis. The pathogenic activity of CagA is partly regulated by tyrosine phosphorylation of C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs in host cells....

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Source

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Identifiers

PMID: 34564597
DOI: 10.3390/toxins13090592
PMCID: PMC8473296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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