Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene.

doi:10.1128/IAI.01951-06

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene.

Infection and immunity - 1 Jul 2007

Reyes-Leon Adriana, Atherton John C, Argent Richard H, Puente J L, Torres J

Abstract excerpt

Helicobacter pylori CagA is translocated into gastric epithelial cells by a type IV secretion system and interacts with the Src homology 2 phosphatase, altering cell morphology. Multiple EPIYA motifs in CagA are associated with increased activity in cells and with gastric cancer. The aim of this work was to study the heterogeneity in activity in cells of multiple H. pylori single colonies isolated from a single...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Antigens, Bacterial
Bacterial Proteins
Cell Line
Child
Epithelial Cells
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Helicobacter Infections

Helicobacter pylori

Humans

Interleukin-8

Male

Mexico

Source

Open in PubMed Open full text

Identifiers

PMID: 17438024
DOI: 10.1128/IAI.01951-06
PMCID: PMC1932923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17438024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene.PMID 17438024Read ↗

Creation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling PathwaysSemantic proximity Read ↗

Individual hosts carry H. pylori isolates with different cagA features - motifs and copy number.Semantic proximity Read ↗

Heterogeneity of cag genotypes and clinical outcome of Helicobacter pylori infection.Semantic proximity Read ↗

Variation in the number of EPIYA-C repeats in CagA protein from Colombian Helicobacter pylori strains and its ability middle to induce hummingbird phenotype in gastric epithelial cells.Semantic proximity Read ↗

Functional Analysis of the<i>cag</i>Pathogenicity Island in<i>Helicobacter pylori</i>Isolates from Patients with Gastritis, Peptic Ulcer, and Gastric CancerSemantic proximity Read ↗

Helicobacter pylori CagA EPIYA Motif Variations Affect Metabolic Activity in B Cells.Semantic proximity Read ↗

Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoproteinSemantic proximity Read ↗

Dynamic Expansion and Contraction of cagA Copy Number in Helicobacter pylori Impact Development of Gastric DiseaseSemantic proximity Read ↗

Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes.Semantic proximity Read ↗

The number of Helicobacter pylori CagA EPIYA C tyrosine phosphorylation motifs influences the pattern of gastritis and the development of gastric carcinomaSemantic proximity Read ↗

Clinical presentation in relation to diversity within the Helicobacter pylori cag pathogenicity island.Semantic proximity Read ↗

The genetic diversity of Helicobacter pylori virulence genes is not associated with gastric atrophy progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.