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Article

Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing.

Development (Cambridge, England) - 15 Oct 2021

White Alisa K, Baumgartner Marybeth, Lee Madisen F, Drake Kyle D, Aquino Gabriela S, Kanadia Rahul N

Abstract excerpt

Minor spliceosome inhibition due to mutations in RNU4ATAC are linked to primary microcephaly. Ablation of Rnu11, which encodes a minor spliceosome snRNA, inhibits the minor spliceosome in the developing mouse pallium, causing microcephaly. There, cell cycle defects and p53-mediated apoptosis in response to DNA damage resulted in loss of radial glial cells (RGCs), underpinning microcephaly. Here, we ablated Trp53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34557915
DOI: 10.1242/dev.199591
PMCID: PMC8572008

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Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing.PMID 34557915Read ↗

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