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Article

Defective minor spliceosomes induce SMA-associated phenotypes through sensitive intron-containing neural genes in Drosophila.

Nature communications - 5 Nov 2020

Li Liang, Ding Zhan, Pang Ting-Lin, Zhang Bei, Li Chen-Hui, Liang An-Min, Wang Yu-Ru, Zhou Yu, Fan Yu-Jie, Xu Yong-Zhen

Abstract excerpt

The minor spliceosome is evolutionarily conserved in higher eukaryotes, but its biological significance remains poorly understood. Here, by precise CRISPR/Cas9-mediated disruption of the U12 and U6atac snRNAs, we report that a defective minor spliceosome is responsible for spinal muscular atrophy (SMA) associated phenotypes in Drosophila. Using a newly developed bioinformatic approach, we identified a large set...

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Identifiers

PMID: 33154379
DOI: 10.1038/s41467-020-19451-z
PMCID: PMC7644725

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