Article

u4atac regulates cilium biogenesis through splicing of the minor intron of tmem107l and rfx7b in zebrafish developing brain

2026-08-24

Abstract excerpt

Bi-allelic variants of RNU4ATAC, transcribed into the minor spliceosome component U4atac snRNA, are associated to variable severity of microcephaly, growth retardation, skeletal dysplasia and immunodeficiency as main features. Previous studies highlighted the dramatic effect of U4atac deficiency on splicing of U12-type introns, which represent less than 1% of all introns in the human genome. More recently, our tea...

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Literature Corpus work: 80b0f483-fde5-5b20-98e1-c33c1de170ae
DOI: 10.64898/2026.08.20.745718

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