Article

<i>Trp53</i> ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing

2021-03-06

Abstract excerpt

Mutations in minor spliceosome component RNU4ATAC, a small nuclear RNA (snRNA), are linked to primary microcephaly. We have reported that in the conditional knockout (cKO) mice for Rnu11 , another minor spliceosome snRNA, minor intron splicing defect in minor intron-containing genes (MIGs) regulating cell cycle resulted in cell cycle defects, with a concomitant increase in γH2aX+ cells and p53-mediated apoptosis....

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Literature Corpus work: 9568ad6a-f91b-5a01-b961-df76491b135d
DOI: 10.1101/2021.03.05.434172

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