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Article

Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls.

Scientific reports - 23 Sept 2021

Heinzel Stephan, Kaufmann Christian, Grützmann Rosa, Klawohn Julia, Riesel Anja, Bey Katharina, Heilmann-Heimbach Stefanie, Weinhold Leonie, Ramirez Alfredo, Wagner Michael, Kathmann Norbert

Abstract excerpt

Alterations in frontal and parietal neural activations during working memory task performance have been suggested as a candidate endophenotype of obsessive-compulsive disorder (OCD) in studies involving first-degree relatives. However, the direct link between genetic risk for OCD and neuro-functional alterations during working memory performance has not been investigated to date. Thus, the aim of the current...

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Identifiers

PMID: 34556731
DOI: 10.1038/s41598-021-98333-w
PMCID: PMC8460640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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