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Article

Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.

The American journal of psychiatry - 1 Feb 2007

Chamberlain Samuel R, Fineberg Naomi A, Menzies Lara A, Blackwell Andrew D, Bullmore Edward T, Robbins Trevor W, Sahakian Barbara J

Abstract excerpt

OBJECTIVE: Obsessive-compulsive disorder (OCD) is highly heritable. Attempts to delineate precise genetic contributions have met with limited success. There is an ongoing search for intermediate cognitive brain markers (endophenotypes) that may help clarify genetic contributions. The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17267798
DOI: 10.1176/ajp.2007.164.2.335
PMCID: PMC1892796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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