Article
Nuclear localization of duck Tembusu virus NS5 protein attenuates viral replication in vitro and NS5-NS2B3 interaction.
Veterinary microbiology - 1 Nov 2021
Zeng Miao, Chen Shun, Zhang Wei, Duan Yanping, Jiang Bowen, Pan Xin, Wang Mingshu, Jia Renyong, Zhu Dekang, Liu Mafeng, Zhao Xinxin, Yang Qiao, Wu Ying, Zhang Shaqiu, Huang Juan, Ou Xumin, Mao Sai, Tian Bin, Gao Qun, Cheng Anchun
Abstract excerpt
Duck Tembusu virus (TMUV) belongs to the flavivirus genus whose genome replication involved in capping and RNA synthesis dominating by nonstructural protein 5 (NS5). Flaviviral replication has been well documented to occur in the cytoplasm, but the effect of NS5 to gain access to the nucleus remains controversial. Here, TMUV NS5 was observed to localize within the cytoplasm of transfected and infected cells and...
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