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Dual spindles assemble in bovine zygotes despite the presence of paternal centrosomes

3 Sept 2021

Abstract excerpt

The first mitosis of the mammalian embryo must partition the parental genomes contained in two pronuclei. In rodent zygotes, sperm centrosomes are degraded, and instead, acentriolar microtubule organizing centers and microtubule self-organization guide the assembly of two separate spindles around the genomes. In nonrodent mammals, including human or bovine, centrosomes are inherited from the sperm and have been...

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PMID: 34550316
DOI: 10.1083/jcb.202010106

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